H2PLX from Priority One^® Nutritional Supplements Inc. was formulated on the following research.

Selenium inhibits the ability of viruses to reproduce.^1,3 Selenium has demonstrated useful immune-enhancing effects in animal and human studies. It has been found to be essential for healthy immune function. Some viruses that are normally benign become pathogenic in those who are selenium deficient. It has been shown to play important roles in T-cells and natural killer cells. Selenium has been shown to stimulate antibody production.⁴

Lithium Orotate: Many over the years associate Lithium with mental illness but it is not a antipsychotic drug as many people believe. In fact lithium isn’t a drug at all. It’s actually a mineral, part of the same family of minerals that includes sodium and potassium.⁵

The antiviral effect of lithium, has been demonstrated in both experimental and clinical conditions. lithium may exert favorable effects on many parameters of cellular and humor immunity.⁶

A randomized, double-blind, placebo-controlled trial of oral lithium therapy in 10 healthy women with chronic, recurrent genital herpes infections, concluded that lithium therapy may be beneficial.⁷

Decades ago, a few people overdosed on lithium, so potentially toxic quantities are available only by prescription. However, low quantities available over-the-counter are helpful, since lithium slows down the formation of the viral capsid (the ‘envelope’ containing the viral nuclear material). If high-dose toxicity ever occurs, it is reversible with essential fatty acids and vitamin E.”1

Melissa Extract (Lemon Balm) 4% Rosemarinic Acid: Numerous test tube studies have found that extracts of lemon balm posses antiviral properties. The predominant theory is that the herb blocks viruses from attaching to cells.⁸

The objective of one study, was to determine the effects of the volatile oil components of Melissa officinalis on Herpes simplex virus type 2 (HSV-2) relocation in HEp-2 cells. Four different concentrations (25,50,100,200 microg/ml) of volatile oils were examined. Experiments were carried out using HEp-2 cells. Melissa officinalis volatile oil was found to be non-toxic to HEp-2 cells up to a concentration of 100 micro/ml. The antiviral activity of non-toxic concentrations against HSV-2 was tested. The replication of HSV-2 was inhibited, indicating that the Melissa officinalis extract contains an anti-HSV-2 substance.”⁹

Vitamin C (ascorbic acid) has been shown to support the immune system. It is thought to increase production of lymphocytes, the white cells important in antibody production and in coordinating cellular immune function.¹⁰

Olive Leaf Extract (olea europaea) The olive leaf is the first botanical mentioned in the Bible. Throughout the history of civilization, the olive plant has been an important source of nutrition and medicine.

OLE contains compounds with potent antimicrobial activities against bacteria, fungi, and mycoplasma. In addition, OLE has antioxidant and anti-inflammatory activities. Some of these effects have been proposed to contribute to the anti-atherogenic properties of a diet rich in olive oil. Some AIDS patients have begun to use OLE for a variety of indications, among them to strengthen the immune system, to relieve chronic fatigue, to boost the effects of anti-HIV medications, and to treat HIV-associated Kaposi’s sarcoma and HSV infections.¹¹

Vitamin A is important for proper function of the immune system. Vitamin A can protect immune function by helping to maintain the integrity of epithelial barriers to infection and by activating phagocytes and cytotoxic T-cells. An in vitro experiment showed that a form of vitamin A found in breast milk inhibits herpes simplex virus-1.12

Vitamin A is used primarily as an immune enhancer in viral illnesses. It is absolutely critical to a healthily functioning immune system. Deficient individuals are susceptible to infectious diseases, particularly viral infections. Then during the course of the ensuing infections, the already low vitamin A stores are severely depleted.¹³

L-Lysine appears to suppress the clinical manifestations of herpes virus infection. In a multi-centered study of lysine therapy of Herpes Simplex infection, forty five patients with frequently recurring herpes infections were given 312-1,200mg of lysine daily in single or multiple doses. The clinical results demonstrated a beneficial effect from supplementary lysine in accelerating recovery from herpes simplex infection and suppressing recurrence.”¹⁴

“In addition to lithium and selenium, lysine, can also help suppress the reproduction of herpes simplex (and other viruses) and speed the recovery process should an active infection occur.”⁵

In order for a patient to keep the virus in check, Dr. Jonathan
Wright MD recommends eliminating all refined sugars and carbohydrates, having a food allergy test to desensitize the patient of all major food allergies.¹⁵

“Herpes virus reproduction (which leads to the outbreak of sores) is stimulated by the amino acid L-arginine. L-arginine is found in higher quantities in foods which can, like viruses, reproduce themselves: nuts (especially peanuts), beans, seed and grains. Cutting back on foods like these that contain higher levels of L-arginine can help reduce outbreaks.”³ Once the immune system is strengthened and desensitized, you can gradually allow some of the eliminated foods, including nuts, back into the diet. In addition to dietary changes, supplement with vitamins and minerals to boost the bodies overall immune function.¹⁶

REFERENCES:top | shop

1. Wright MD, Dr. Jonathan V. “Herpes: An alternative solution to an ongoing problem.” Nutrition & Healing Newsletter, Oct 2001, http://www.wrightnewsletter.com.
2. Gaby A.,R., “Natural remedies for herpes simplex.” Altern Med Rev, 2006 Jun;11(2):93-101. http://www.ncbi.nlm.nih.gov/PMID16813459.
3. Wright MD, Dr. Jonathan V. “Become a sore loser with this simple herpes solution.” Nutrition & Healing Newsletter, Nov 2004, p.7. http://www.wrightnewsletter.com.
4. PDR for Nutritional Supplements first edition, Thomson 2001, p 419.
5. Wright MD, Dr. Jonathan V. “Importance of Lithium Supplementation” Nutrition & Healing Newsletter, Sept 2003. http://www.wrightnewsletter.com
6. Rybakowski JK. “Antiviral and immunomodulatory effect of lithium.” Pharmacopsychiatry, 2000 Sep; 33 (5):159-64. http://www.ncbi.nlm.nih.gov/PMID 11071016.
7. Amsterdam JD, Maislin G, Potter L, Giuntoli R. “Reduced rate of recurrent genital herpes infections with lithium carbonate.” Psychopharmol Bull, 1990;26(3):343-7, http://www.ncbi.nlm.nih.gov/ PMID 2125737.
8. http://healthlibrary.epnet.com, lemon balm.
9. Allahverdiyev A., Duran N., Ozguven M., Koltas S. “Antiviral activity of the volatile oils of Melissa officinials L. against Herpes simplex virus type 2.” Phytomedicine., 2004 Nov;11(7-8):657-61.
10. Haas, Elson M. MD, Staying Healthy with Nutrition: the complete guide to diet and nutritional medicine, Celestial Arts, Berkeley CA, 1992 pp.141-7.
11. S. Lee-Huang et al. / Biochemical and Biophysical Research Communications 307 (2003) 1029–1037, www.nyu.edu
12. PDR for Nutritional Supplements first edition, Thomson 2001, p465-6
13. Michael T. Murray, ND Encyclopedia of Nutritional Supplements, Prima Health,1996; p.27, 30.
14. Griffith R.S., Norins A.L., Kagan C., “A multicentered study of lysine therapy in Herpes Simplex infection.” Dermatologica, 1978;156(5):257-67, http://www.ncbi.nlm.nih.gov/ PMID 640102
15. Wright MD, Dr. Jonathan V. “Help for herpes.” Etips archives, Nutrition & Healing Newsletter, http://www.wrightnewseltter.com/etips/ht200507/ht20050718.html
16. Wright MD, Dr. Jonathan V. “Warts n’All.” Etips archives, Nutrition & Healing Newsletter, Nov 2004, http://www.wrightnewsletter.com.

Lifenol^® (hops extract) is a patented plant extract. It contains stable and guaranteed levels of prenylflavonoids, including 8-prenylnaringenin (8-PN), a molecule recognized for its oestrogenic properties. A randomized, double-blind, placebo-controlled clinical trial, concluded; daily intake of hops extract, standardized on 8-PN, a potent phytoestrogen, exerted favorable effects on vasomotor symptoms and other menopausal discomforts.³

Isoflavone (from soy bean extract): Foods high in phytoestrogens (chemical compounds that the body can convert into usable estrogents) are thought to reduce the frequency and severity of hot fl ashes. Japanese women have far fewer hot fl ashes than American women and researchers have correlated this with the traditional Japanese diet, including soybean foods which are high in phytoestrogens.⁴

AvoVida^® (avocado/soy unsaponifiables) is an all-natural vegetable extract standardized to contain a minimum of 30% phytosterols from avocado and soy oils. Key ingredients in AvoVida^® are the plant sterols beta-sitosterol, stigmasterol, and campesterol.⁵

Black Cohosh (Cimicifuga racemosa): The primary pharmacologic effects of black cohosh appear to revolve around its ability to impact endocrine regulatory mechanisms, which appear to be the result of complex synergistic actions of its key ingredients. Black cohosh is thought to benefit those with hot fl ashes, depression and vaginal atrophy.⁶

Dong Quai (Angelica sinensis) has been shown to support a healthy balance of female hormones.⁷ It is rich in vitamins and minerals and this has made it popular in traditional Chinese medicine. It’s efficiency in hot fl ashes may be due to a combination of its mild estrogenic effects coupled with other components acting to stabilize blood vessels.⁸

Licorice Root: Active constituents of licorice include glycyrrhizic acid, isoflavonol, kumatakenin, licoricone and glaborol. The estrogenic action of glycyrrhiza is due to its isoflavone content.⁹

Chasteberry (Vitex angus-castus): Chasteberry is thought to be a beneficial phytomedicine for hormonal imbalances in women.⁷ The benefits are thought to be from a regulatory effect on the pituitary gland.¹⁰ Findings confirm a normalizing action on the estrogen-progesterone balance.¹¹

Referencestop | shop

1. http://www.menopause.org/MF200901two_menpausestatus.aspx
2. http://soynutrition.com/SoyHealth/SoyAndMenopause.html
3. Heyerick A, Vervarcke S, Depypere H, Bracke M, De Keukeleire D., Maturitas. 2006 May 20;54(2):164-75. A first prospective, randomized, double-blind, placebo-controlled study on the use of a standardized hop extract to alleviate menopausal discomforts. Laboratory of Pharmacognosy and Phytochemistry, Ghent University-UGent, Harelbekestraat 72, 9000, and Department of Gynaecological Oncology, Ghent University Hospital, Ghent, Belgium
4. Aldercrutz, H. Amer J. Clin Nutr. 54 #6 (1994) pg 1093-1100.
5. http://www.cyvex.com Cyvex Nutrition Inc. AvoVida ingredient 2007.
6. Pizzorno, Joseph E. Jr, Murray, Michael T., Textbook of Natural Medicine, Churchill Livingstone Elsevier, St. Louis, MI 2006 Vol 1 pg. 848.
7. Ritchason, Jack ND, The Little Herb Encyclopedia,Third Edition, Woodland Health Books, Pleasant Grove, UT, 1995 pg. 74.
8. Brantner, F. Ehk 28, 1979, pg 413.
9. Pizzorno, Joseph E. Jr, Murray, Michael T., Textbook of Natural Medicine, Churchill Livingstone Elsevier, St. Louis, MI 2006 Vol 1 pg. 1003-1004.
10. Attelman, H. Agnolyt. Geriatre 2, 1972 pg 239.
11. Kayser, H. PMS. Hippokrates 25 (25) pg 717.

AvoVida^® is a registered trademark of Cyvex Nutrition Inc.

Lifenol^® is a registered trademark of Naturex

Powerful Two Phase Digestive Enzyme Formulas! Exclusive enteric matrix formula allows for pHSensitive Release.

Different enzymes are active at different pH levels. The exclusive enteric matrix formulation of Enzy-Gest^TM and Hypo-Gest^TM allow for two-phase, pH-sensitive release of enzymes. The first phase being released in the stomach (gastric phase) and the second in the upper intestine (enteric phase).

Incomplete Digestion Can Cause Food Allergies and Many Diseasestop | shop

Proper digestion is a requirement of optimum health, and incomplete or disordered digestion can be a major contributor to the development of many diseases. Not only are foods and nutritional substances of little benefit when breakdown and assimilation are inadequate, but also, incompletely digested food molecules can be inappropriately absorbed into the systemic circulation. This can lead to various diseases and the development of food allergies.¹

Enzymatic action originates in four areas: the salivary glands, the stomach, the pancreas and the wall of the small intestine. Each enzyme is capable of breaking down only a specific substance. For example, an enzyme capable of breaking down fats cannot break down proteins or carbohydrates or vice versa.²

Gastric Phase Releases Pepsin, Papain and Needed Acidstop | shop

The stomach is primarily responsible for digestion of proteins and ionization of minerals. The stomach secretes gastric acid (hydrochloric acid) and various hormones and enzymes.¹ In Enzy-Gest^TM and Hypo-Gest^TM the gastric release phase provides the protein digestive enzymes pepsin and Papain. Betaine HCI (a source of hydrochloric acid) and glutamic acid add needed acids to the stomach to improve digestion.

PAPIN is the protein-digesting enzyme isolated from the unripe papaya fruit. It has been shown to be able to digest wheat gluten (the protein portion of wheat) and render it harmless in celiac disease subjects. Taking a Papain supplement with meals may allow some individuals to tolerate gluten.^1,9,10

PEPSIN Another function of the stomach is to break large proteins into smaller peptides and peptones. The acidic environment in the stomach does not harbor many enzymes. The primary enzyme in the stomach is pepsin, used to digest proteins. Pepsin breaks up proteins into smaller peptides of varying lengths. Although much has been said about hyperacidity (as often occurs with peptic ulcers), probably more significant health problems are caused by lack of gastric acid secretion. There are may symptoms and signs that suggest impaired gastric acid secretion, and a number of specific diseases have been found to be associated with insufficient gastric acid output.^{1, 9, 10}

Several studies have shown that the ability to secrete gastric acid decreases with age. Low stomach acidity has been found in over half of those over age 60.^{1, 5, 6}

Common symptoms of low gastric acidity include:

• Bloating, belching, burning and flatulence immediately after meals.¹
• A sense of “fullness” after eating¹
• Indigestion, diarrhea or constipation¹
• Multiple food allergies¹
• Nausea after taking supplements¹

Other signs of low gastric acidity include weak, peeling and cracked fingernails, dilated blood vessels in the cheeks and nose (in non-alcoholics), acne, iron deficiency, chronic intestinal parasites or abnormal flora, undigested food in the stool, chronic candida infections, and upper digestive tract gassiness.¹

Enteric Phase Releases Digestive Enzymes and Biletop | shop

PANCREATIN In a study on the therapeutic response to oral enzymes in severe pancreatic insufficiency, researchers conclude that “…the administration of these high potency digestive aids, along with meals, doesn’t have a very positive clinical influence on reducing malabsorption through improved digestion – when comparing a healthy pancreatic sufficient individual to one with pancreatic insufficiency, the use of pancreatin with meals greatly increases the fat splitting enzyme activity in the duodenum to nearly normal levels.¹⁵

Oral enzyme supplements have been effectively used therapeutically in case of:

• Food allergies.
• Toxic bowl syndrome resulting from overgrowth of gastrointestinal bacteria.¹⁵
• Malabsorption caused by pancreatic insufficiency resulting from cystic fibrosis, alcoholism or surgical resection of portions of the pancreas¹³ or high fat diet.¹⁴
• Pancreatectomy of chronic pancreatitis.
• Systemic parasites.
• Enhancements of B-12 absorption

The small intestine participates in all aspects of digestion, absorption and transport of ingested materials. It secretes a variety of digestive and protective substances as well as receiving the secretions of the pancreas, liver and gallbladder.²

Diseases involving the small intestine often result in malabsorption syndromes characterized by multiple nutrient deficiencies. Common causes of malabsorption include celiac disease (gluten intolerance), food allergy or intolerance, intestinal infections and Crohn’s disease.¹

BROMELAIN a protein-digesting enzyme found in pineapple, is useful as an aid to protein digestion and is effective as a substitute for pancreatic enzymes in the treatment of pancreatic insufficiency.^1,8

PANCREATIC AMYLASE Digest starch, dextrins and glycogen, converting them to maltose, a disaccharide.

PANCRELIPASE along with bile, functions in the digestion of fats. Deficiency of lipase results in malabsorption of fats and the fat-soluble vitamins.¹

OX BILE Aids in the production of an alkaline reaction in the intestines and is essential for absorption of fats.¹² Bile emulsifies the fats, permitting intestinal and pancreatic lipases to split the triglycerides into diglycerides and monoglycerides, and finally into free fatty acids and glycerol.⁷

REFERENCES:top | shop

1. Murray, Michael and Pizzorno, Joseph, Encyclopedia of Natural Medicine, Prima Publishing, Rocklin, CA. 1991, pp. 43, 50-56.
2. Kirshchmann, John and Dunne, Lavon, Nutrition Almanac, Second Edition, McGraw Hill, NY, 1984.
3. Carper, W.M., Butler, T.J., Kilby, J.O. and Gibson, M.J., “Gallstones, gastric secretion and flatulent dyspepsia”, Lancet, i, pp. 413-15.
4. Rabinowitch, I.M., “Achlorhydria and its clinical significance in diabetes mellitus” Am. J. Dig. Dis., 1949, 18, pp. 322-33.
5. Rafsky, H.A. and Weingarten, M., “A study of the gastric secretory response in the aged”, Gastroent., 1946, May, pp. 348-52.
6. Davies, D. and James, T.G., “An investigation into the gastric secretory of a hundred normal persons over the age of sixty”, Brit. Med. J., 1930, i, pp. 1-14.
7. Garrison, R.H. and Somer, E., The Nutrition Desk Reference, Keats Publishing, New Canaan, CT, 1985. pp. 31-32.
8. Taussig, S., Yokoyama, M., Chinen, Al, et al., “Bromelain, a proteolytic enzyme and its clinical application. A review”, Hiroshima J. Med. Sci., 1975, 24, pp. 185-93.
9. Messer, M., Anderson, C.M. and Hubbard, L., Studies on the mechanism of destruction of the toxic action of wheat gluten in celiac disease by crude Papain”, Gut., 19664, 5. pp. 295-303.
10. Messer, M. and Baume, P., “Oral Papain in gluten intolerance”, Lancet, 1976, i, pp. 1,022.
11. Rubenstein, E., Mark, Z., Haspel, J, et al. “Antibacterial activity of the pancreatic fluid”. Gastroenterol., 1985, 89, pp. 392-7.
12. Dorland, W.A.N., The American Illustrated Medical Dictionary, Twenty-first Edition, W.B. Saunders, Co., Philadelphia, PA. 1947.
13. Graham, David Y., M.D., “Enzyme Replacement Therapy of Exocrine Pancreatic Insufficiency in Man”. New England Journal of Medicine 196:1314-1317. June 9, 1977.
14. Bland, Jeffrey, Ph.D., “Glandular Based Food Supplements: Helping to Separate Facts from Fiction”. University of Puget Sound, 1980.
15. DiMagno, E.P., “Comparative Effects of Antacids, Cimetidine and Enteric Coating on the Therapeutic Response to Oral Enzymes in Severe Pancreatic Insufficiency”, New England Journal of Medicine, 197:854-858, October 20, 1977.
16. Cichoke, Anthony J., D.C., “The use of Proteolytic Enzymes with Soft Tissue Athletic Injuries”. The American chiropractor p. 32, September/October, 1981.

Humans are exposed to heavy metals through the environment and from things we consume.

Of the heavy metals, toxicity by chronic lead exposure is the most commonly encountered. The National Health and Nutrition Examination Survey (NHANES III), conducted from 1988-1990, found that 0.4% of persons aged 1 year and older had blood levels of lead of 25mcg/dL or higher. The data also noted that, among those aged 1-5 years, an estimated 1.7 million children had blood levels greater than 10 mcg/dL. The syndrome of childhood plumbism caused by the ingestion of lead is believed to affect more than 2 million American pre-school-aged children.¹

Several studies demonstrate the effectiveness of DMSA.^2,3,4,5,6

Usage:top | shop

A multi-mineral supplement should be taken between courses of DMSA and for several weeks thereafter to avoid deficiencies.

DMSA is given as an oral supplement on an empty stomach.

Dosages and duration depend on age, gender, exposure, and weight, using 10mg/kg divided into three doses as a common starting point.² Dosages as high as 30mg/kg/day have been shown to be safe and effective.¹

One protocol may be 500mg every other day for 4-5 weeks. Another option is 200mg of DMSA three times a day for three days, followed by 14 days off. This cycle can then be repeated several times. 24-hour urine collections should be used as a guide for duration of use. Children and sensitive individuals must be closely monitored and dosage adjusted accordingly.^8,9

References:top | shop

1. http://emedicine.medscape.com/article/814960-overview
2. Pizzorno JE, Murray M, Textbook of Natural Medicine (3rd ed) Vol. 1. Churchill Livingstone Elsevier, St. Louis, Missouri 2006, pg. 269.
3. Sompamit K, Kukongviriyapan U, Donpunha W, Nakmareong S, Kukongviriyapan V., Faculty of Medicine, Mahasarakham University, Mahasarakham 44000, Thailand. Toxicol Lett.2010 Apr 22. PMID: 20399841
4. Ruha AM, Curry SC, Gerkin RD, Caldwell KL, Osterloh JD, Wax PM. Department of Medical Toxicology, Banner Good Samaritan Medical Center, Phoenix, AZ 85006, USA. Arch Pathol Lab Med. 2009 Jan;133(1):87-92. PMID: 19123743
5. Kokayi K, Altman CH, Callely RW, Harrison A. Olive Leaf Wholeness Center, New York, NY, USA. Explore (NY). 2006 Sep-Oct;2(5):400-7. PMID:16979103
6. Michaeli-Yossef Y, Berkovitch M, Goldman M. Department of Pediatrics, Assaf Harofeh Medical Center, Zerifi n, 70300, Israel. Pediatr Nephrol. 2007 Jun;22(6):903-6. Epub 2007 Feb 20. PMID: 17310361
7. Bradberry S, Sheehan T, Vale A. Use of oral dimercaptosuccinic acid (succimer) in adult patients with inorganic lead poisoning. QJM. 2009 Oct;102(10):721-32. Epub 2009 Aug 20.
8. Blanusa M, Varnai VM, Piasek M, Kostial K. Chelators as antidotes of metal toxicity: Therapeutic and experimental aspects. Curr Med Chem. 2005;12(23):2771-94.
9. Miller AL. Dimercaptosuccinic acid (DMSA), a non-toxic, water-soluble treatment for heavy metal toxicity. Altern Med Rev. 1998 Jun;3(3):199-207

Bioflavonoids are a group of naturally-occurring compounds that act as powerful antioxidants. Synergistic with Vitamin C, bioflavonoids help support the immune system. Flavonoids in general, and quercitin specifically, inhibit the release of histamine. Quercitin has been shown to slow the formation of histamine and other allergic response mediators.¹

Echinacea purpurea decreases mild inflammatory reactions and contains high molecular weight polysaccharides known to be immune modulators.² Echinacea is well established as an immune-stimulant, anti-inflammatory, antibacterial, and antiviral agent.

Nettle leaves (Urtica dioica) contain the glycosides of flavonoids, phenylpropanoids, sterols, carotenoids, vitamins, and minerals.³ In a study published in 2009, nettle leaf extract displayed in vitro inhibition of several key inflammatory events that cause the symptoms of seasonal allergies. These include the antagonist and negative agonist activity against the Histamine-1 receptor and the inhibition of mast cell tryptase, preventing degranulation and release of a host of pro-inflammatory mediators.⁴

Enzyme therapy may be helpful to those with allergies. Enzymes can break down protein allergens and work to block the process that causes allergic reaction. Systemic enzyme therapy is used to reduce inflammation, stimulate the immune system, improve circulation, transport nutrients throughout the body, and remove waste products.⁵ Proteolitic enzymes in combination with flavonoids, as found in Allergy Plus^TM, have been shown to potentiate each other’s anti-inflammatory activity.⁶

RECOMMENDED DOSAGE: Three capsules between meals (two hours after or one hour before) three times daily; or may be taken every hour between meals as needed.

References:top | shop

1. Murray, M., Pizzorno, J. Encyclopedia of Natural Medicine. Prima Health. p. 451.
2. Tilgner, S., Herbal Medicine from the Heart of the Earth. Wies Acres Press, Creswell. p. 59.
3. Bisset N.G., Wichtl M., eds. Herbal drugs and phytopharmaceuticals. Stuttgart: Medpharm Scientifi c Pub, 1994.
4. Roschek, B., Jr, Fink, R.C., McMichael M, Alberte RS. “Nettle extract (Urtica dioica) affects key receptors and enzymes associated with allergic rhinitis.” Phytother Res. 2009 23(7):920-6.
5. Cichoke, A., Allergies, Complete Book of Enzyme Therapy. p. 112. 1999
6. Murray, M., Pizzorno, J. Textbook of Natural Medicine Third Edition. p. 971. 2006

Vitamin A is essential to proper immune response. It has been shown to strengthen the cell wall, giving mucous membrane protection, and is thought to exhibit anti-viral properties.

Vitamin C is necessary for maintaining connective tissue integrity; it also aids in the function of red blood cells and the maintenance of lymphocytes, acts as a synergist for other vitamins and minerals, supports proper immune function, and increases the production of interferon.²

Garlic (Allium sativa): Garlic is one of the most well-recognized medicinal herbs. It is used in traditional medicines all over the world, and its applications are as varied as its geographical distribution. The chemistry and pharmacology of garlic is well studied; it is thought to possess numerous multi-faceted antimicrobial properties including bacterial, enzyme, and anti-fungal; it is also an expectorant and digestive stimulant.³

Vitamin B-6 deficiency is said to affect both humoral and cell mediated immune responses.⁴ It appears to protect nucleic acids and promote T-type lymphocyte production; it is also necessary for proper zinc utilization, an important co-factor in antibody production and it aids in fluid regulation via the kidneys. Vitamin B6 is called the “diuretic” vitamin since it can help the body drain excess water.

Bioflavonoids (Citrus) It has been shown that the action of both vitamin C and bioflavonoids are enhanced when the two are taken together. This combination may benefit those with inflammation by inhibiting the release of histamines and other inflammatory substances into the tissues.

Zinc has been shown to support immune response synergistically with vitamin A. Zinc is also involved in prostaglandin formation as well as in increasing thyroid and thymic hormone output.⁵

Magnesium aids in the relaxation of muscles, promotes utilization of vitamins B and C, and aids in the body’s acid-base and electrolyte balance.

Myrrh resin (Balsamodendron myrrh) has been shown to have antiseptic, stimulant, tonic, expectorant, and vulnerary properties. An ancient Bible remedy still in use today, it is valuable as a tonic and stimulant for bronchial and lung health.⁶

Ginger (Zingiber officinalis): Ginger is widely used as a medicinal herb in Chinese and Ayurvedic medicine, often added to herbal formulas to support digestion and the activity of other herbs. Ginger has become best known for its anti-nausea and anti-motion sickness properties. It has been shown to act on the gastrointestinal system to allay nausea.⁷ Unlike the leading over-the-counter drug, Dramamine®, ginger does not relieve nausea by suppressing central nervous system activity. Rather, the effect is explained by the antiemetic (preventing or relieving nausea and vomiting) effects of the herb, which are well documented.⁷

Cayenne (Capsicum annuum): Cayenne, or red pepper, is regarded as a general tonic, most useful as a systemic stimulant. It increases blood fl ow, and is thought to strengthen the heartbeat and metabolic rate.^{8, 9, 10}

Barberry root (Berberis vulgaris), Oregon grape root (Berberis aquifoluim): The value of these herbs involves their high content of isoquinoline alkaloids, the most widely studied being berberine. Berberine is said to have a broad spectrum of antibiotic activity; it also has displayed antimicrobial activity against bacteria, protozoa, and fungi.¹¹ Berberine is thought to provide many benefits in support of a healthy immune response.

Echinacea root (E. angustifolia, E. purpurea) is known for immune system support. Its effects are provided through a synergistic combination of constituents, including polysaccharides, alkylamides, caffeic acid, flavonoids, essential oils, and polyacetylenes.¹² Echinacea has been shown to increase white blood cell count, and, thus support the body’s ability to handle bacteria and viruses, stimulate T lymphocyte activity, and support the lymphatic system to clear waste.¹³ Root extracts have also been shown to possess interferon-like properties.¹⁴

Among the complex constituents of Echinacea are insulin, sucrose, betaine, and echinacoside (a caffeic acid glycoside). Betaine is said to have antispectic properties. The combination of betaine and caffeic acid is said to act as a blood purifier and internal decongestant. Insulin is rapidly absorbed into the kidneys, where it is thought to cleanse and support that organ as well as surrounding organs (i.e., liver, spleen, pancreas).

Referencestop | shop

1. Cohen, S., Tyrell, D.A.J., and Smith, A.P. “Psychological Stress and Susceptibility to the Common Cold.“ New England Journal of Medicine 325 no. 9 (Aug. 1991 606-612).
2. Cheraskin, E., M.D. “Vitamin C: Who Needs It.” Birmingham, AL. Arlington Press, 1993.
3. Foster, S. “Garlic, Botanical Series 311.” Austin, TX: American Botanical Council. 1991.
4. Pubmed.gov 1993 Aug;51(8):217-25. “Vitamin B6 and Immune Competence.” Rall LC, Meydani SN. Nutritional Immunology Laboratory, USDA Human Nutrition Research Center on Aging, Tufts University, Boston.
5. Chandra, R.K. Trace Elements, Immunity and Infection. Wiley, New York (1983).
6. Kloss, Jethro, “Back to Eden” pg. 160, 1939.
7. Bone, M.E.: et al. “Ginger Root- a New Antiemetic: The Effect of Ginger Root on Postoperative Nausea and Vomiting After Major Gynecological Surgery.” Anesthesia 42 no. 8 (Aug. 1990): 669-671.
8. Henry, C.J., and Emery, B. “Effect of Spiced Food on Metabolic Rate” Human Nutrition, Clinical Nutrition. 40 No.2 (Mar. 1986): 165-168.
9. Glatzel, H. “Treatment of Dyspeptic Disorders with Spice Extracts” Hippkrates 49 No. 23 (Dec. 1969): 916-919. (Published in German).
10. Glatzel, H. “Blood Circulation Effectiveness of Natural Spices” Med. Lin. 62 No. 51 (Dec. 1967): 1987-1989. (Published in German).
11. Pizzorno, J. and Murray, M. “Berberne-Containing Botanicals.” Textbook of Natural Medicine Third Edition. pg.1014-1015, 2006.
12. Pizzorno, J. and Murray, M. “Echinacea Species, Chemical Composition.” Textbook of Natural Medicine Third Edition. pg.907-908, 2006.
13. Haas, Elson, M.D. ”Echinacea.” Staying Healthy with Nutrition. pg.276, 1992.
14. Wacker, A. and Hilbig, W. “Virus-inhibition by echinacea purpurea” Planta Medica 33:89-102,1978.

It can be argued that the adrenal glands are the organs most commonly (although unknowingly) abused by people today as a result of our hurried and harrowed lifestyles. As a result, symptoms such as fatigue, poor sleep, brain fog, headaches, digestive dysfunction, difficulty handling stress, and high blood pressure are commonplace. However, as the father of modern stress research, Dr. Hans Selye, states “Stress is not…necessarily bad for you; it is also the spice of life, for any emotion, any activity causes stress.” Therefore, it is not the stressor but the individual’s response to stress that determines a positive or negative outcome.

The adrenal glands help control and regulate how our body responds to stress through a three phase process known as the “general adaptation syndrome.” Phase one, known as the alarm phase, is usually short-lived. Adrenaline is the hormone most active during this phase-triggering a “fight or flight” response. The second phase is the resistance reaction. During this phase, cortisol and other adrenal cortex hormones are secreted to help provide energy, deal with circulatory changes, and manage the physiological changes that occur secondary to prolonged stress. In times of danger, this phase is necessary for survival. However, extended periods of time spent in the resistance phase increases the chance of developing diabetes, hypertension, cancer, and other chronic diseases.¹ Exhaustion is the third and final phase of the general adaptation syndrome. Chronic stress depletes adrenal hormone production and places a significant burden on various organ systems.

Adrenoplex^TM is a comprehensive formula addressing the adrenal glands, from the smallest biochemical factors to the entire desiccated gland. Adrenoplex provides glandular support along with vitamins, minerals, and herbs to support the immune system, relieve stress, enhance metabolism, and aid the body in combating the negative effects of chronic stress. This approach leads to a broader therapeutic potential while still providing specific nutrients shown to improve adrenal function.

Adrenoplex may be helpful for:

• Generalized stress
• Fatigue and decreased energy levels
• Poor carbohydrate and fat metabolism
• Adrenal insufficiency
• Counteracting the negative effects of cortisone use
• Immune system support

Glandular concentrates are chosen for their similarities to the human body and work via the principle that “like heals like.” Glandular supplements provide a balance of key nutrients to promote regeneration and maintenance of glands. Adrenoplex^TM contains three glandular concentrates: pituitary, adrenal cortex, and whole adrenal gland.

Pituitary: The pituitary is considered the control center of endocrine function. The alert phase of the general adaptation syndrome begins with pituitary secretion of ACTH (adrenocorticotropic hormone), which stimulates the adrenals to secrete adrenaline producing a fight or flight response. The addition of pituitary gland allows for an “upstream” approach to treatment by supporting the gland-controlling adrenal activity.

Adrenal Cortex: The adrenal cortex is responsible for producing three types of hormones: mineralocorticoids (aldosterone), glucocorticoids (cortisol), and androgen hormones (testosterone). The resistance phase of the general adaptation syndrome is primarily the result of cortisol and other hormones secreted by the adrenal cortex.¹ Adrenal cortex extracts may also contain corticosteroids, which can be helpful for cases of allergy and inflammation.

Adrenal: The addition of the entire adrenal gland is believed to provide the needed cofactors to aid in assimilation. By providing the entire gland along with the adrenal cortex concentrate, the interaction between cofactors, enzymes, hormones, vitamins, and minerals involved in the overall function of the gland can be used together. Adaptogenic herbs are those considered to balance function and improve overall function by increasing the ability of an organism to adapt to environmental factors and avoid damage from such factors. The benefit of adaptogens is primarily associated with positive effects on the hypothalamic-pituitary-adrenal (HPA) axis, the part of the stress system believed to play a role in the body’s response to repeated stress.²

Eleuthro Root (Eleutherococcus senticosus) is referred to as an adrenal adaptogen and has been shown to produce a number of beneficial effects on the body. These include:

• Increased mental performance and physical working capacity²
• Increased energy
• Immunomodulatory effects – increased NK cells³ and potential inhibition of RNA viral replication⁴
• Anti-inflammatory effects through the inhibition of cyclooxygenase 25
• Enhancement of the body’s response to stress⁶

Licorice Root: Glycyrrhetinic acid has been shown to have aldosterone-like effects on the body.⁷ Its primary effects occur in the liver through the suppression of 5-beta reductase, the enzyme responsible for the inactivation of cortisol, aldosterone, and progesterone.⁸ This may be of great benefit in cases of extreme adrenal insufficiency.

Pantothenic Acid: Pantothenic acid is required for the synthesis of steroid hormones produced in the adrenal glands.¹⁰ A deficiency of pantothenic acid may lead to adrenal atrophy causing symptoms such as fatigue, headache, sleep disturbances, and digestive complaints.¹

Ascorbic Acid: Urinary excretion of vitamin C is increased in times of stress.¹ In addition, stimulation of ACTH (adrenocorticotropic hormone) leads to a decrease of ascorbic acid from the adrenal cortex.¹⁰ Because vitamin C has antioxidant qualities and immune support properties, replenishment during times of stress is essential.

Zinc: Important in the overall function of the adrenal glands and in hormone synthesis. Low levels of zinc are associated with a decrease in T-cell function.¹⁰

Beta Carotene: Anti-oxidant used to combat the free radical damage associated with prolonged stress. Beta carotene has also been shown to have immune support properties which may aid the body’s natural defenses during times of stress.⁹

Bibliographytop | shop

1. Murray, Michael, and Joseph Pizzorno. Textbook of Natural Medicine. Churchill Livingstone, 1999.
2. Panossian, A, and H. Wagner. “Stimulating effect of adaptogens: an overview with particular reference to their efficacy following single dose administration.” Phytotherapy Research, 2005: 819-38.
3. Tang W, Eisenbrand G. Chinese Drugs of Plant. Heidelberg: Springer Verlag, 1992.
4. Glatthaar-Saalmuller B, Sacher F, Esperester A. “Antiviral activity of an extract derived from roots of Eleutherococcus senticosus.” Antiviral Res, 2001: 223-228.
5. Bu Y, Jin ZH, Park SY, et al. “Siberian ginseng reduces infarct volume in transient focal cerebral ischaemia in Sprague-Dawley rats.” Phytother Res, 2005: 167-169.
6. Facchinetti F, Neri I, Tarabusi M. “Eleutherococcus senticosus reduces cardiovascular response in healthy subjects: a randomized, placebo-controlled trial.” Stress Health, 2002: 11-17.
7. Wash LK, Bernard JD. “Licorice-induced pseudoaldosteronism.” Am J Hosp Pharm, 1975: 73-74.
8. Tamura, Y, T Nishikawa, and K. Yamada. “Effects of glycyrrhetinic acid and its derivatives on delta4-5-alpha and 5-beta-reductase in rat liver.” Arzneim Forsch, 1979: 647-649.
9. Bendich, A. “Beta carotene and the immune response.” Proc Nutr Soc, 1991: 1306-12.
10. Marz, Russell. Medical Nutrition from Marz. Portland: Omni-Press, 1997.

References:top | shop

1. Hypocortisolemia in graves hyperthyroidism. Karl M, Onumah BM, Cole J, Golding J, Burman KD, Wartofsky L. Endocr Pract. 2009 May-Jun;15(3):220-4.
2. Reversible subclinical hypothyroidism in the presence of adrenal insufficiency. Abdullatif HD, Ashraf AP. Endocr Pract. 2006 Sep-Oct;12(5):572.
3. Deep negative T waves associated with reversible left ventricular dysfunction in acute adrenal crisis. Iga K, Hori K, Gen H. Heart Vessels. 1992;7(2):107-11.

The mechanism of action of 5-MTHF involves the homocysteine pathway as well as acting as a co-factor in production of nitric oxide, a blood vessel vasodilator. 5-MTHF acts on the homocysteine pathway by donating its methyl group to homocysteine,along with vitamin B12, in order for the cycle to move forward. When there are low levels of either 5-MTHF or B12 in the blood, homocysteine accumulates, and the pathway cannot proceed. High levels of homocysteine have been found to be associated with atherosclerosis, hardening and narrowing of the arteries,as well as an increased risk of stroke and heart attack. Studies have shown that after 5-MTHF supplementation is administered,homocysteine levels decrease, and optional homocysteine metabolism occurs. 5-MTHF also supports optimal blood fl ow by helping in the synthesis of nitric oxide. In atherosclerosis, there can be impaired nitric oxide production, leading to vasoconstriction and hardening of the arteries, thereby making a person more susceptible to cardiovascular disease. Therefore, 5-MTHF helps in both decreasing homocysteine levels as well as increasing nitric oxide levels to provide overall support for cardiovascular health.

In addition to cardiovascular health, 5-MTHF plays a significant role in mental health. Going back to the homocysteine pathway, the end product of 5-MTHF and vitamin B12 joining with homocysteine is a molecule called S-adenosylmethionine (SAMe). SAMe plays a major role in the production of neurotransmitters including dopamine and serotonin, two neurotransmitters that have been studied extensively in the role of depression and other affective disorders. A recent meta-analysis of 11 studies (N of 15,315) found a significant relationship between risk of depression and low folate status. Other studies have found that as many as 1/3 of people with major depression have a folic acid deficiency; thereby,these people are unable to produce SAMe and will have lower levels of serotonin and dopamine.

Additional research has found that taking folic acid along with anti-depressant pharmaceuticals significantly improves the effects of the therapy. A recent study found that anti-depressants were no more effective than placebos in mild or moderate depression, which accounts for 87% of people diagnosed with depression.

There are other actions that folate has in the body beyond decreasing levels of homocysteine and increasing neurotransmitter levels. Various other actions include DNA synthesis, regulation of gene expression, amino acid synthesis and metabolism,and myelin synthesis and repair. Studies have shown that it also plays a role in nerve health as well as with dysplastic changes. Further research is encouraged, considering the potential for this nutrient to help in ways beyond those that research has already discovered. Thus, with the information that is already available and the fact that this is anon-toxic substance, it seems evident that getting one’s daily requirement of the active form of folate can be important in overall health and well-being. And there should always be an emphasis on getting our nutrients from food. Foods that are high in folate include green leafy vegetables, sprouts, citrus fruits, brewer’s yeast, and organ meats. These are important to eat, and one should also keep in mind that the supplemental form, 5-MTHF, is available for optimal absorption and, therefore, therapeutic benefits.

References:top | shop

1. Winkels RM et al. Bioavailability of food folates is 80% of that of folic acid. American Journal of Clinical Nutrition. 2007 Feb;85(2):465-73.
2. Miller AL. The methylation, neurotransmitter, and antioxidant connections between folate and depression. Altern Med Rev. 2008 Sep;13(3):216-26.
3. Lin CP et al. Anti-inflammatory strategies for homocysteine-related cardiovascular disease. Front Biosci. 2009 Jan 1;14:3836-45.
4. Monograph: 5-Methyltetrahydrofolate. Alternative Medicine Review, Dec, 2006.
5. Coppen A, Bolander-Gouaille C. Treatment of depression: time to consider folic acid and vitamin B12. Journal Pscyhoparmacol. 2005 Jan;19(1):59-6
6. Fournier, Jay C. Antidepressant Drug Effects and Depression Severity. JAMA. 2010;303(1):47-53
7. Fava M, Mischoulon D. Folate in depression: efficacy, safety,differences in formulations, and clinical issues. Journal Clinical Pyschiatry. 2009;70 Suppl 5:12-7.

• Immune system support by increasing phagocytes, T-cells, and B-cells¹
• Easily assimilated protein²
• Supports DNA repair³
• Neutralizes and eliminates some heavy metals⁴
• Increases red blood cells, white blood cells, platelets, and albumin⁵

Effects on Immunitytop | shop

“Chlorella helps protect the body in its fight against…viruses. A study on chlorella published in Japan in 1992 showed that chlorella has impressive effects on blood chemistry. It increases red blood cells, white bloods cells, platelets, and albumin. Chlorella is truly an important supplement for anyone whose albumin level is low.”⁵ Albumin is one of the body’s most powerful antioxidants as well as its main transport system, carrying vitamins, minerals, fatty acids, hormones, and other essential substances throughout the body. Albumin is also instrumental in carrying toxins away from cells into the liver, where they are broken down and later excreted from the body. Without adequate levels of albumin, the kidneys, liver, and other vital organs cannot do their jobs as well, and the immune system cannot function as effi ciently. Numerous studies have documented that a low albumin level is a marker for serious illness… They point to test-tube studies confi rming that raising albumin levels can ‘extend the life span of human cells.’ Although no such studies have been done on humans, it makes sense that raising albumin levels would help to restore health.”⁶ “Chlorella has been shown to improve immune function in people undergoing chemotherapy, and/or radiation therapy. Chlorella increases macrophage activity and activates both T-cells, and B-cells. In addition, a substance found in chlorella stimulates interferon production. Chlorella is a whole food rich in many phytochemicals, some of which have been identifi ed, but many of which are still unknown. A group of elements referred to as chlorella growth factor, or CGF, is believed to be one group of compounds in chlorella that give it health-promoting ability. Chlorella stimulates the growth of friendly bacteria, which in turn has the probiotic effect of strengthening gut fl ora and resisting disease.”⁵ “Since Chlorella has a true nucleus, it is a more advanced organism than the other common green micro-algae and therefore may offer superior-quality RNA/DNA. This particular aspect of its RNA/DNA, measured by the ‘Chlorella Growth Factor’ (CGF), strengthens immunity by improving the activity of Tand B-cells, which defend against viruses and other invading micro-organisms and macrophages, which destroy…cellular debris in general.”⁷

Detoxifyingtop | shop

“Chlorella can neutralize and eliminate some of the contaminating heavy metals and strengthen the immune system, and GLA, which enhances prostaglandin production and possesses anti-inflammatory abilities.”⁴ “It helps clear toxic metals from the body. Chlorella has anti-infl ammatory properties and strengthens the immune system. The microalgae support normal growth and help maintain health in old age.”⁸

Referencestop | shop

1. Tierra, Michael, Dr. LAc,ND,AHG, Treating Cancer with Herbs An Integrative Approach, Lotus Press, Twin Lakes, WI, 2003, pg 361.
2. Tierra, Treating Cancer with Herbs. pg 268.
3. Tierra, Michael, Dr., LAc,ND,AHG, The Way of Herbs, Pocket Books Publishing, Aug. 1998, pg. 309.
4. Null, Gray, Ph.D., Complete Encyclopedia of Natural Healing, Kensington Publishing Corporation, Oct. 2005, pg. 135.
5. Yance, Donald R. Jr., CN, M.H., A.H.G, Herbal Medicine, Healing & Cancer, Keats Publishing, Lincolnwood, IL, 1999, pg. 230-1.
6. Mindell, Earl RPh, Ph.D., Earl Mindell’s Supplement Bible, Pocket Books Publishing, June 2002, pg24.
7. Pitchford, Paul, Healing with Whole Foods, North Atlantic Books Publishing, Sept. 2002, pg. 194.
8. Wood, Rebecca, New Whole Food Encyclopedia: A Comprehensive Resource for Healthy Eating, Penguin Group Publishing, July 1999, pg. 81.