Priority One Adrenoplex


It can be argued that the adrenal glands are the organs most commonly (although unknowingly) abused by people today as a result of our hurried and harrowed lifestyles. As a result, symptoms such as fatigue, poor sleep, brain fog, headaches, digestive dysfunction, difficulty handling stress, and high blood pressure are commonplace. However, as the father of modern stress research, Dr. Hans Selye, states “Stress is not…necessarily bad for you; it is also the spice of life, for any emotion, any activity causes stress.” Therefore, it is not the stressor but the individual’s response to stress that determines a positive or negative outcome.

The adrenal glands help control and regulate how our body responds to stress through a three phase process known as the “general adaptation syndrome.” Phase one, known as the alarm phase, is usually short-lived. Adrenaline is the hormone most active during this phase-triggering a “fight or flight” response. The second phase is the resistance reaction. During this phase, cortisol and other adrenal cortex hormones are secreted to help provide energy, deal with circulatory changes, and manage the physiological changes that occur secondary to prolonged stress. In times of danger, this phase is necessary for survival. However, extended periods of time spent in the resistance phase increases the chance of developing diabetes, hypertension, cancer, and other chronic diseases.1 Exhaustion is the third and final phase of the general adaptation syndrome. Chronic stress depletes adrenal hormone production and places a significant burden on various organ systems.

AdrenoplexTM is a comprehensive formula addressing the adrenal glands, from the smallest biochemical factors to the entire desiccated gland. Adrenoplex provides glandular support along with vitamins, minerals, and herbs to support the immune system, relieve stress, enhance metabolism, and aid the body in combating the negative effects of chronic stress. This approach leads to a broader therapeutic potential while still providing specific nutrients shown to improve adrenal function.

Adrenoplex may be helpful for:

  • Generalized stress
  • Fatigue and decreased energy levels
  • Poor carbohydrate and fat metabolism
  • Adrenal insufficiency
  • Counteracting the negative effects of cortisone use
  • Immune system support

Glandular concentrates are chosen for their similarities to the human body and work via the principle that “like heals like.” Glandular supplements provide a balance of key nutrients to promote regeneration and maintenance of glands. AdrenoplexTM contains three glandular concentrates: pituitary, adrenal cortex, and whole adrenal gland.

Pituitary: The pituitary is considered the control center of endocrine function. The alert phase of the general adaptation syndrome begins with pituitary secretion of ACTH (adrenocorticotropic hormone), which stimulates the adrenals to secrete adrenaline producing a fight or flight response. The addition of pituitary gland allows for an “upstream” approach to treatment by supporting the gland-controlling adrenal activity.

Adrenal Cortex: The adrenal cortex is responsible for producing three types of hormones: mineralocorticoids (aldosterone), glucocorticoids (cortisol), and androgen hormones (testosterone). The resistance phase of the general adaptation syndrome is primarily the result of cortisol and other hormones secreted by the adrenal cortex.1 Adrenal cortex extracts may also contain corticosteroids, which can be helpful for cases of allergy and inflammation.

Adrenal: The addition of the entire adrenal gland is believed to provide the needed cofactors to aid in assimilation. By providing the entire gland along with the adrenal cortex concentrate, the interaction between cofactors, enzymes, hormones, vitamins, and minerals involved in the overall function of the gland can be used together. Adaptogenic herbs are those considered to balance function and improve overall function by increasing the ability of an organism to adapt to environmental factors and avoid damage from such factors. The benefit of adaptogens is primarily associated with positive effects on the hypothalamic-pituitary-adrenal (HPA) axis, the part of the stress system believed to play a role in the body’s response to repeated stress.2

Eleuthro Root (Eleutherococcus senticosus) is referred to as an adrenal adaptogen and has been shown to produce a number of beneficial effects on the body. These include:

  • Increased mental performance and physical working capacity2
  • Increased energy
  • Immunomodulatory effects – increased NK cells3 and potential inhibition of RNA viral replication4
  • Anti-inflammatory effects through the inhibition of cyclooxygenase 25
  • Enhancement of the body’s response to stress6

Licorice Root: Glycyrrhetinic acid has been shown to have aldosterone-like effects on the body.7 Its primary effects occur in the liver through the suppression of 5-beta reductase, the enzyme responsible for the inactivation of cortisol, aldosterone, and progesterone.8 This may be of great benefit in cases of extreme adrenal insufficiency.

Pantothenic Acid: Pantothenic acid is required for the synthesis of steroid hormones produced in the adrenal glands.10 A deficiency of pantothenic acid may lead to adrenal atrophy causing symptoms such as fatigue, headache, sleep disturbances, and digestive complaints.1

Ascorbic Acid: Urinary excretion of vitamin C is increased in times of stress.1 In addition, stimulation of ACTH (adrenocorticotropic hormone) leads to a decrease of ascorbic acid from the adrenal cortex.10 Because vitamin C has antioxidant qualities and immune support properties, replenishment during times of stress is essential.

Zinc: Important in the overall function of the adrenal glands and in hormone synthesis. Low levels of zinc are associated with a decrease in T-cell function.10

Beta Carotene: Anti-oxidant used to combat the free radical damage associated with prolonged stress. Beta carotene has also been shown to have immune support properties which may aid the body’s natural defenses during times of stress.9


  1. Murray, Michael, and Joseph Pizzorno. Textbook of Natural Medicine. Churchill Livingstone, 1999.
  2. Panossian, A, and H. Wagner. “Stimulating effect of adaptogens: an overview with particular reference to their efficacy following single dose administration.” Phytotherapy Research, 2005: 819-38.
  3. Tang W, Eisenbrand G. Chinese Drugs of Plant. Heidelberg: Springer Verlag, 1992.
  4. Glatthaar-Saalmuller B, Sacher F, Esperester A. “Antiviral activity of an extract derived from roots of Eleutherococcus senticosus.” Antiviral Res, 2001: 223-228.
  5. Bu Y, Jin ZH, Park SY, et al. “Siberian ginseng reduces infarct volume in transient focal cerebral ischaemia in Sprague-Dawley rats.” Phytother Res, 2005: 167-169.
  6. Facchinetti F, Neri I, Tarabusi M. “Eleutherococcus senticosus reduces cardiovascular response in healthy subjects: a randomized, placebo-controlled trial.” Stress Health, 2002: 11-17.
  7. Wash LK, Bernard JD. “Licorice-induced pseudoaldosteronism.” Am J Hosp Pharm, 1975: 73-74.
  8. Tamura, Y, T Nishikawa, and K. Yamada. “Effects of glycyrrhetinic acid and its derivatives on delta4-5-alpha and 5-beta-reductase in rat liver.” Arzneim Forsch, 1979: 647-649.
  9. Bendich, A. “Beta carotene and the immune response.” Proc Nutr Soc, 1991: 1306-12.
  10. Marz, Russell. Medical Nutrition from Marz. Portland: Omni-Press, 1997.